Dose Response Study of Aqueous Extract of Dialium Guineense Stem Bark

Background and Objective: What distinguishes a poison from remedy is dose. The safety of plant-derived bioactive compounds has become global concern. present study investigated the dose response aqueous extract Dialium guineense stem bark using Wistar rats. Methods: Adult male rats (n=30) weighing 160-180 g (mean weight =170 ± 20 g) were randomly assigned to six groups five each. medicinal plant was obtained cold maceration method. received varied doses (200-2000 mg/kg body weight, bwt) orally with aid gavage for period 28 days (4 weeks). Concentration Fasting Blood Glucose (FBG) used as therapeutic index. Results: Aqueous D. significantly reduced FBG levels normal (p<0.05). graded quantal curves showed that 1000 bwt effective in reducing blood glucose (produced best hypoglycemic effect).